Recent Publications
2025
A Bead-Based Quantum Dot Immunoassay Integrated with Multi-Module Microfluidics Enables Real-Time Multiplexed Detection of Blood Insulin and Glucagon. Abouali H, Srikant S, Fattah MFA, Barra NG, Chan D, Ban D, Schertzer JD, Poudineh M. Adv Sci (Weinh). 2025 Apr 25:e2412185. doi: 10.1002/advs.202412185. PMID: 40278502 PubMed Link
GDF15 links adipose tissue lipolysis with anxiety. Townsend LK, Wang D, Knuth CM, Fayyazi R, Mohammad A, Becker LJ, Tsakiridis EE, Desjardins EM, Patel Z, Valvano CM, Lu J, Payne AE, Itua O, Medak KD, Marko DM, Schertzer JD, Wright DC, Beaudette SM, Morrison KM, Carpentier AC, Blondin DP, MacPherson REK, McCall JG, Jeschke MG, Steinberg GR. Nat Metab. 2025 May;7(5):1004-1017. doi: 10.1038/s42255-025-01264-3. PMID: 40234625 PubMed Link
Microbiota protect against frailty and loss of skeletal muscle, and maintain inflammatory tone during aging in mice. Conn MO, DeJong EN, Marko DM, Fayyazi R, Kukje Zada D, Foley KP, Barra NG, Bowdish DME, Schertzer JD. Am J Physiol Cell Physiol. 2025 Mar 1;328(3):C887-C894. doi: 10.1152/ajpcell.00869.202. PMID: 39925101 PubMed Link
Food supply toxicants and additives alter the gut microbiota and risk of metabolic disease. Barra NG, Fang H, Bhatwa A, Schmidt AM, Syed SA, Steinberg GR, Morrison KM, Surette MG, Wade MG, Holloway AC, Schertzer JD. Am J Physiol Endocrinol Metab. 2025 Mar 1;328(3):E337-E353. doi: 10.1152/ajpendo.00364.2024. PMID: 39871724 PubMed Link
Not So Fast: Intermittent Fasting Fails to Improve Metabolic Flexibility in Mice With Obesity and Type 2 Diabetes. Conn MO, Marko DM, Schertzer JD. Physiology (Bethesda). 2025 Jul 1;40(4):0. doi: 10.1152/physiol.00060.2024. PMID: 39718947 PubMed Link
Postbiotic Impact on Host Metabolism and Immunity Provides Therapeutic Potential in Metabolic Disease. Fang H, Rodrigues E-Lacerda R, Barra NG, Kukje Zada D, Robin N, Mehra A, Schertzer JD. Endocr Rev. 2025 Jan 10;46(1):60-79. doi: 10.1210/endrev/bnae025. PMID: 39235984 PubMed Link
2024
NOD2 protects against allergic lung inflammation in obese female mice. Rodrigues E-Lacerda R, Barra NG, Fang H, Anhê GF, Schertzer JD. iScience. 2024 Oct 11;27(11):111130. doi: 10.1016/j.isci.2024.111130.PMID: 39507249 PubMed Link
Intermittent fasting increases fat oxidation and promotes metabolic flexibility in lean mice but not obese type 2 diabetic mice. Conn MO, Marko DM, Schertzer JD. Am J Physiol Endocrinol Metab. 2024 Oct 1;327(4):E470-E477. doi: 10.1152/ajpendo.00255.2024. PMID: 39196802 PubMed Link
Bruton's tyrosine kinase (BTK) inhibitors alter blood glucose and insulin in obese mice but reduce inflammation independent of BTK. Chan DY, Barra NG, Fang H, Rodrigues E-Lacerda R, Schertzer JD. Am J Physiol Endocrinol Metab. 2024 Sep 1;327(3):E271-E278. doi: 10.1152/ajpendo.00205.2024. PMID: 39017678. PubMed Link
Wearable Aptalyzer Integrates Microneedle and Electrochemical Sensing for In Vivo Monitoring of Glucose and Lactate in Live Animals. Bakhshandeh F, Zheng H, Barra NG, Sadeghzadeh S, Ausri I, Sen P, Keyvani F, Rahman F, Quadrilatero J, Liu J, Schertzer JD, Soleymani L, Poudineh M. Adv Mater. 2024 Aug;36(35):e2313743. doi: 10.1002/adma.202313743. PMID: 38752744 PubMed Link
Intermittent fasting influences immunity and metabolism. Marko DM, Conn MO, Schertzer JD. Trends Endocrinol Metab. 2024 Sep;35(9):821-833. doi: 10.1016/j.tem.2024.04.014. PMID: 38719726 PubMed Link
2023
Intestinal permeability and peripheral immune cell composition are altered by pregnancy and adiposity at mid- and late-gestation in the mouse. Ribeiro TA, Breznik JA, Kennedy KM, Yeo E, Kennelly BKE, Jazwiec PA, Patterson VS, Bellissimo CJ, Anhê FF, Schertzer JD, Bowdish DME, Sloboda DM. PLoS One. 2023 Aug 7;18(8):e0284972. doi: 10.1371/journal.pone.0284972. PMID: 37549142 PubMed Link
Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes. Rodrigues E-Lacerda R, Fang H, Robin N, Bhatwa A, Marko DM, Schertzer JD. Biomed J. 2023 Oct;46(5):100610. doi: 10.1016/j.bj.2023.100610. PMID: 37263539 PubMed Link
Obesity promotes a leaky gut, inflammation and pre-diabetes by lowering gut microbiota that metabolise ethanolamine. Fang H, E-Lacerda RR, Schertzer JD. Gut. 2023 Oct;72(10):1809-1811. doi: 10.1136/gutjnl-2023-329815. PMID: 37105722 PubMed Link
Dietary Nitrate and Corresponding Gut Microbiota Prevent Cardiac Dysfunction in Obese Mice. Petrick HL, Ogilvie LM, Brunetta HS, Robinson A, Kirsh AJ, Barbeau PA, Handy RM, Coyle-Asbil B, Gianetto-Hill C, Dennis KMJH, van Loon LJC, Chabowski A, Schertzer JD, Allen-Vercoe E, Simpson JA, Holloway GP. Diabetes. 2023 Jul 1;72(7):844-856. doi: 10.2337/db22-0575. PMID: 36812497 PubMed Link
Associations of intrapartum antibiotics and growth, atopy, gastrointestinal and sleep outcomes at one year of age. Hutton EK, Simioni JC, Thabane L; Baby & Mi Research Team; Morrison KM. Pediatr Res. 2023 Sep;94(3):1026-1034. doi: 10.1038/s41390-023-02525-1. Epub 2023 Feb 18. PMID: 36807614 PubMed Link
Kinase inhibitors for cancer alter metabolism, blood glucose, and insulin. Duggan BM, Marko DM, Muzaffar R, Chan DY, Schertzer JD. J Endocrinol. 2023 Jan 9;256(2):e220212. doi: 10.1530/JOE-22-0212. PMID: 36476560 PubMed Link
2022
Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice. Kwon YH, Banskota S, Wang H, Rossi L, Grondin JA, Syed SA, Yousefi Y, Schertzer JD, Morrison KM, Wade MG, Holloway AC, Surette MG, Steinberg GR, Khan WI. Nat Commun. 2022 Dec 20;13(1):7617. doi: 10.1038/s41467-022-35309-y. PMID: 36539404 PubMed Link
Dietary sugar lowers immunity and microbiota that protect against metabolic disease. Fang H, Anhê FF, Schertzer JD. Cell Metab. 2022 Oct 4;34(10):1422-1424. doi: 10.1016/j.cmet.2022.09.006. PMID: 36198287 PubMed Link
High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake independently of changes in thermogenesis and the gut microbiome. Richard G, Blondin DP, Syed SA, Rossi L, Fontes ME, Fortin M, Phoenix S, Frisch F, Dubreuil S, Guérin B, Turcotte ÉE, Lepage M, Surette MG, Schertzer JD, Steinberg GR, Morrison KM, Carpentier AC. Cell Rep Med. 2022 Sep 20;3(9):100742. doi: 10.1016/j.xcrm.2022.100742. PMID: 36130480 PubMed Link
Postbiotics engage IRF4 in adipocytes to promote sex-dependent changes in blood glucose during obesity. Duggan BM, Singh AM, Chan DY, Schertzer JD. Physiol Rep. 2022 Aug;10(16):e15439. doi: 10.14814/phy2.15439. PMID: 35993451 PubMed Link
Increased gut serotonin production in response to bisphenol A structural analogs may contribute to their obesogenic effects. Barra NG, Kwon YH, Morrison KM, Steinberg GR, Wade MG, Khan WI, Vijayan MM, Schertzer JD, Holloway AC. Am J Physiol Endocrinol Metab. 2022 Jul 1;323(1):E80-E091. doi: 10.1152/ajpendo.00049.2022. PMID: 35575233 PubMed Link
Metformin-induced reductions in tumor growth involves modulation of the gut microbiome. Broadfield LA, Saigal A, Szamosi JC, Hammill JA, Bezverbnaya K, Wang D, Gautam J, Tsakiridis EE, Di Pastena F, McNicol J, Wu J, Syed S, Lally JSV, Raphenya AR, Blouin MJ, Pollak M, Sacconi A, Blandino G, McArthur AG, Schertzer JD, Surette MG, Collins SM, Bramson JL, Muti P, Tsakiridis T, Steinberg GR. Mol Metab. 2022 Jul;61:101498. doi: 10.1016/j.molmet.2022.101498. PMID: 35452877 PubMed Link
Life-long exercise training and inherited aerobic endurance capacity produce converging gut microbiome signatures in rodents. Anhê FF, Zlitni S, Barra NG, Foley KP, Nilsson MI, Nederveen JP, Koch LG, Britton SL, Tarnopolsky MA, Schertzer JD. Physiol Rep. 2022 Mar;10(5):e15215. doi: 10.14814/phy2.15215. PMID: 35246957 PubMed Link
Insulin resistance corresponds with a progressive increase in NOD1 in high fat diet-fed mice. Sharma A, Singh S, Mishra A, Rai AK, Ahmad I, Ahmad S, Gulzar F, Schertzer JD, Shrivastava A, Tamrakar AK.Endocrine. 2022 May;76(2):282-293. doi: 10.1007/s12020-022-02995-z. PMID: 35112215 PubMed Link
Determining the metabolic impact of postbiotics in mice. Anhê FF, Bhatwa A, Schertzer JD. STAR Protoc. 2022 Jan 13;3(1):101098. doi: 10.1016/j.xpro.2021.101098.PMID: 35072117 PubMed Link
Exploration of BAY 11-7082 as a Potential Antibiotic. Coles VE, Darveau P, Zhang X, Harvey H, Henriksbo BD, Yang A, Schertzer JD, Magolan J, Burrows LL. ACS Infect Dis. 2022 Jan 14;8(1):170-182. doi: 10.1021/acsinfecdis.1c00522. PMID: 34860493 PubMed Link
Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice. Duggan BM, Tamrakar AK, Barra NG, Anhê FF, Paniccia G, Wallace JG, Stacey HD, Surette MG, Miller MS, Sloboda DM, Schertzer JD. Mol Metab. 2022 Jan;55:101404. doi: 10.1016/j.molmet.2021.101404.PMID: 34839023 PubMed Link
2021
Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota. Ahmed BA, Ong FJ, Barra NG, Blondin DP, Gunn E, Oreskovich SM, Szamosi JC, Syed SA, Hutchings EK, Konyer NB, Singh NP, Yabut JM, Desjardins EM, Anhê FF, Foley KP, Holloway AC, Noseworthy MD, Haman F, Carpentier AC, Surette MG, Schertzer JD, Punthakee Z, Steinberg GR, Morrison KM. Cell Rep Med. 2021 Sep 14;2(9):100397. doi: 10.1016/j.xcrm.2021.100397. PMID: 34622234 PubMed Link
Metabolic endotoxemia is dictated by the type of lipopolysaccharide. Anhê FF, Barra NG, Cavallari JF, Henriksbo BD, Schertzer JD. Cell Rep. 2021 Sep 14;36(11):109691. doi: 10.1016/j.celrep.2021.109691. PMID: 34525353 PubMed Link
Low dietary fiber promotes enteric expansion of a Crohn's disease-associated pathobiont independent of obesity. Lau TC, Fiebig-Comyn AA, Shaler CR, McPhee JB, Coombes BK, Schertzer JD. Am J Physiol Endocrinol Metab. 2021 Sep 1;321(3):E338-E350. doi: 10.1152/ajpendo.00134.2021. PMID: 34280051 PubMed Link
Micronutrients impact the gut microbiota and blood glucose. Barra NG, Anhê FF, Cavallari JF, Singh AM, Chan DY, Schertzer JD. J Endocrinol. 2021 Jul 28;250(2):R1-R21. doi: 10.1530/JOE-21-0081. PMID: 34165440 PubMed Link
Iron Reshapes the Gut Microbiome and Host Metabolism. Botta A, Barra NG, Lam NH, Chow S, Pantopoulos K, Schertzer JD, Sweeney G. J Lipid Atheroscler. 2021 May;10(2):160-183. doi: 10.12997/jla.2021.10.2.160. PMID: 34095010 PubMed Link
Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases. Anhê FF, Jensen BAH, Perazza LR, Tchernof A, Schertzer JD, Marette A. J Lipid Atheroscler. 2021 May;10(2):123-129. doi: 10.12997/jla.2021.10.2.123. PMID: 34095007 PubMed Link
Effects of Obesity-Associated Chronic Inflammation on Peripheral Blood Immunophenotype Are Not Mediated by TNF in Female C57BL/6J Mice. Breznik JA, Foley KP, Maddiboina D, Schertzer JD, Sloboda DM, Bowdish DME. Immunohorizons. 2021 Jun 4;5(6):370-383. doi: 10.4049/immunohorizons.2100038. PMID: 34088851 PubMed Link
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment. Poznanski SM, Singh K, Ritchie TM, Aguiar JA, Fan IY, Portillo AL, Rojas EA, Vahedi F, El-Sayes A, Xing S, Butcher M, Lu Y, Doxey AC, Schertzer JD, Hirte HW, Ashkar AA. Cell Metab. 2021 Jun 1;33(6):1205-1220.e5. doi: 10.1016/j.cmet.2021.03.023. PMID: 33852875 PubMed Link
Inflammation promotes adipocyte lipolysis via IRE1 kinase. Foley KP, Chen Y, Barra NG, Heal M, Kwok K, Tamrakar AK, Chi W, Duggan BM, Henriksbo BD, Liu Y, Schertzer JD. J Biol Chem. 2021 Jan-Jun;296:100440. doi: 10.1016/j.jbc.2021.100440.PMID: 33610548 PubMed Link
Peripheral and central regulation of insulin by the intestine and microbiome. Schertzer JD, Lam TKT. Am J Physiol Endocrinol Metab. 2021 Feb 1;320(2):E234-E239. doi: 10.1152/ajpendo.00547.2020. PMID: 33308015 PubMed Link
NOD1 activation induces oxidative stress via NOX1/4 in adipocytes. Sharma A, Singh S, Ahmad S, Gulzar F, Schertzer JD, Tamrakar AK. Free Radic Biol Med. 2021 Jan;162:118-128. doi: 10.1016/j.freeradbiomed.2020.11.036. PMID: 33279617 PubMed Link